Clinical Research

GLP-1 Clinical Research

Peer-reviewed evidence on GLP-1 medications: pivotal trial data, mechanism of action, cardiovascular and renal outcomes, contraindications, and drug interactions.

Mechanism of Action
Detailed pharmacology: GLP-1 receptor binding in CNS, pancreas, GI tract. G…
STEP Trial Results
STEP-1 through STEP-8 — trial designs, populations, primary endpoints. STEP…
SURMOUNT Trial Results
SURMOUNT-1 (NEJM 2022): 22.5% weight loss at 72 weeks. PMID 35658024. SURMO…
SELECT Trial
Lincoff et al., NEJM 2023. n=17,604 adults with overweight/obesity and esta…
FLOW Trial
Perkovic et al., NEJM 2024. n=3,533 adults with T2D and CKD. 24% reduction …
SUSTAIN Trials
SUSTAIN-1 through SUSTAIN-10. SUSTAIN-6 (NEJM 2016) established 26% MACE re…
GLP-1 Contraindications and Boxed Warnings
Personal/family history of medullary thyroid carcinoma (MTC). Multiple Endo…
GLP-1 Drug Interactions
Insulin co-administration and dose adjustment. Sulfonylureas. Oral medicati…